Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance

Integrins are cell adhesion receptors, which typically transmembrane glycoproteins that connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical events within cells. Understanding mechanisms growth is important in elucidating their effects on tumor progression. One major integrin signaling binding ligands. Another event distant gathers chemical signals from outside and transmit upon inside cell. In normal breast tissue, as checkpoints monitor proliferation, while cancer tissue these functions altered. combination microenvironment its associated components determines fate. Hypoxia can increase expression several integrins. exosomal promote metastatic Expression certain with increased metastasis decreased prognosis cancers. addition, integrin-binding proteins invasion cancer. Targeting specific may provide new therapeutic approaches for therapies. This review will examine current knowledge integrins’ role